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KMID : 0605619980050010114
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Journal of Korean Society of Biological Psychiatry
1998 Volume.5 No. 1 p.114 ~ p.121
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The Effects of Coadministration of Haloperidol and Bethanechol on Plasma Haloperidol and Reduced Haloperidol Concentrations
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1김형섭/1Hyeong Seob Kim
1안지영/1여운태/2조숙행/1Jee young Ahn/1Un Tae Yeo/2Suk Haeng Jo
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Abstract
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Bethanechol, a cholinergic agonist, has been recommended for the management of
peripheral anticholinergic side effects during the treatment of antipsychotic medications.
But there have been few studies which have evaluated the drug interactions of
antipsychotics and bethanechol, even the treatment effects of bethanechol on
anticholinergic side effects. So the authors have evaluated whether psychopathology and
plasma haloperidol and reduced haloperidol concentrations are significantly changed or
not when bethanechol was administrated with maintained doses of haloperidol and other
coadministrated drugs(such a benztropine). Also we have evaluated the abating effects
of bethanechol on anticholinergic side effects during the treatment with haloperidol.
Fifteen schizophrenics with higher than 5 of total score of anticholinergic side effects
of 'Rating scale for side effect' were assigned to two groups, and bethanechol 30mg/day
and 60mg/day were applied on each group for 4 weeks. The daily haloperidol dosages
were fixed before 2 weeks of study. We assessed anticholinergic side effects by 'Rating
scale for side effect' and psychopathology by BPRS, and plasma haloperidol and reduced
haloperidol concentrations by HPLC at baseline, 2nd week and 4th week.
The results were as followed.
1) There was no significant change of plasma haloperidol and reduced haloperidol
concentration.
2) At baseline, the dosage of haloperidol showed significant correlation with the total
score of anticholinergic side effect, but not at 2nd week and 4th week.
3) In 60mg/day group, dry mouth and the total score of anticholinergic side effects
were significantly improved, but not in 30mg/day group.
4) There was no significant change of BPRS except withdrawal at 2nd week.
These results suggest that coadministration of bethanechol influenced neither on
psychopathology nor on plasma haloperidol and reduced haloperidol concentrations and
that improved dry mouth and total score of anticholinergic side effects at 60mg/day.
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KEYWORD
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